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Credit Pacific Service Union The government sharply changed its stance on drug treatment to prevent thyroid cancer after a nuclear emergency, saying children should be treated at far lower anticipated levels of radiation exposure than previously recommended.

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Credit First Service Union The Food and Drug Administration issued new treatment guidelines today, emphasizing that the benefits of immediate therapy with the drug potassium iodide, also known by its chemical symbol, KI, far outweigh the rare instances of dangerous side effects, particularly in children, who are more likely than adults to develop thyroid cancer from radiation exposure. The drug, which is available over the counter, works by preventing the thyroid gland from taking up radioactive iodine, which can cause cancer.

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Card Credit Mobile Service The agency has been working on the new guidelines since long before the terrorist attacks of Sept. 11, but those attacks have added an urgency. Officials at the Nuclear Regulatory Commission say they have been waiting for the F.D.A. to finish its work so they can begin negotiations with pharmaceutical companies to manufacture the drug in large quantities, which the commission plans to offer free to states that want to include its use in their emergency plans.

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Card Credit Discover Service The drug agency stressed that the biggest benefit came from treatment with the drug as soon as an alert is issued, ideally before exposure occurs, a finding that sharply challenged the workability of existing emergency response plans in communities with nuclear plants. Many existing plans provide potassium iodide only for emergency workers.

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Credit Public Service Union Implicit in this conclusion was the idea that the drug, to be most effective, should be in communities near power plants, even in household medicine cabinets, so it can be given at the first warning of impending exposure.

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Card Credit Processing Service "Although we don't make any specific recommendations in this regard, the implication from such a fact is that it needs to be available so they can take it when it's called for,"said Dr. David G. Orloff, the director of the F.D.A. division of metabolic and endocrine drug products.

Center Credit Service Union "Any systems for ensuring availability of KI to the public should recognize the critical importance of KI administration in advance of exposure," the agency said in the new document, which it posted on its Web site today (fda.gov/cder/guidance/ 4825fnl.htm).

Card Credit Service Wireless Early action is critical because it takes three to four hours for a dose of potassium iodide to affect the thyroid, flushing it with harmless iodine and preventing the absorption of radioactive iodine, officials said.

Credit Security Service Union Public health experts have talked for years about how to make sure the drug is available promptly. Dr. Jacob Robbins, a scientist emeritus at the National Institutes of Health, said in an interview, "To me, the smart thing to do would be to have it in homes, in blister packs with adhesive backs."

Credit Report Service The core conclusion in the document, which is the first revision of the agency's stance on the drug since 1982, was that KI should be available for immediate use to children in harm's way after a radiation release, because the great benefits of prompt treatment decline rapidly as treatment is delayed.

Blogspot Com Christian The agency sharply lowered the exposure threshold at which children should be given the drug and replaced two recommended dosages one for infants under a year old, and one for everyone else with a list of dosages tailored to age and weight.

Christian Counseling Credit It also sharply raised the level of radioactive exposure at which adults over 40 should take the drug, saying that some side effects were more likely in adults and the cancer-preventing benefits less likely.

Credit Federal Service Union The new recommendations repeat earlier warnings that people with iodine allergies, which they may recognize as allergies to shellfish, people with kidney failure and people on certain blood-pressure drugs like ACE inhibitors should not take KI. Such people are at risk for excessively high blood levels of potassium, which can cause heart problems.

Credit Monitoring Service Historically in the United States, people most at risk for thyroid cancer have included those who had radiation to the head, neck or chest. In the past, radiation was used to treat conditions like acne and enlarged tonsils in young people, a practice that was abandoned.

Credit Division Service Since the Three Mile Island accident of March 1979, the Nuclear Regulatory Commission has reversed itself several times on whether states should have the drug on hand, but in the last two years it has set aside $800,000 to buy stockpiles.

Card Credit Online Service New York State stockpiles KI for emergency workers, like fire and police personnel, and current plans call for administering the pills when the anticipated exposure is 25 rem (a measure of absorbed radiation). A spokesman for the state Emergency Management Office, Donald Maurer, said today that "when the F.D.A. comes out with something like this, we have to take a look at it."

Consumer Counseling Credit Inc Radioactive iodine is one of many products created when reactors split uranium to make heat. Released from a reactor, it can be absorbed directly by people, where it is naturally concentrated by the body in the thyroid, just as normal iodine is. Or it can settle on grass, where it is eaten by cows and concentrated in their milk; once the milk is drunk, the iodine again goes to the thyroid, where it gives off its radiation over the next few weeks. KI stops that by flooding the thyroid with normal iodine, leaving no room for any more.

Card Credit Fleet Service By Matthew L. Wald with Andrew C. Revkin
New York Times - 12/11/2001

Topic: Nuclear

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